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Science 30 October 1970:
Vol. 170. no. 3957, pp. 552 - 553
DOI: 10.1126/science.170.3957.552
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Phosphorylation Coupled to the Transfer of Electrons from Glutathione to Cytochrome c

Audrey A. Painter 1 and F. Edmund Hunter Jr. 1

1 Pharmacology Department, Washington University Medical School, St. Louis, Missouri 63110

Formation of adenosine diphosphate from adenosine monophosphate and inorganic phosphate can be coupled to the oxidation of reduced glutathione by cytochrome c in a reaction which requires oxidized glutathione as a catalyst. The reaction occurs with purified materials in tris(hydroxymethyl)aminomethane buffer and may represent the type reaction for one or more oxidative phosphorylations.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)