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Science 30 October 1970:
Vol. 170. no. 3957, pp. 549 - 550
DOI: 10.1126/science.170.3957.549
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Articles

Monosodium Glutamate-Induced Brain Lesions: Electron Microscopic Examination

Edward A. Arees 1 and Jean Mayer 1

1 Department of Nutrition, Harvard University, School of Public Health, Boston, Massachusetts 02115

Albino mice injected with monosodium glutamate developed brain lesions in the arcuate nucleus of the hypothalamus. Lesions involved primarily microglial cells with no effect to the perikarya of neurons. Distal neuronal processes were only slightly affected.


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Monosodium Glutamate: Absence of Hypothalamic Lesions after Ingestion by Newborn Primates.
W. A. Reynolds, N. Lemkey-Johnston, L. J. Filer Jr., and R. M. Pitkin (1971)
Science 172, 1342-1344
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