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Science 23 October 1970:
Vol. 170. no. 3956, pp. 460 - 462
DOI: 10.1126/science.170.3956.460
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Articles

Plasticizers from Plastic Devices: Extraction, Metabolism, and Accumulation by Biological Systems

Rudolph J. Jaeger 1 and Robert J. Rubin 1

1 Department of Environmental Medicine, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205

Phthalate ester plasticizers were found to be extracted by blood from plastic tubing and from plastic bags used for blood storage. One such plasticizer was metabolized by the isolated perfused rat liver while another was found to be accumulated in the liver unchanged. In addition, this latter plasticizer was identified in samples of human tissue taken from patients who had received transfusions of blood stored in plastic bags. The biological implications of these observations are considered.


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Use of Polymeric Plasticizers in Polyvinyl Chloride to Reduce Conventional Plasticizer Migration for Critical Applications.
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Studies By the National Toxicology Program On Di(2-Ethylhexyl)Phthalate.
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Assessment of Possible Carcinogenic Risk to Humans Resulting from Exposure to Di(2-ethylhexyl)phthalate (DEHP).
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The Biologic Basis for the Clinical Application of the Silicones: A Correlate to Their Biocompatibility.
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Arch Surg 119, 843-848
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Sustained Flexibility in Infant Feeding Tubes Containing Nonmigrating Plasticizer.
G. R. Pereira, R. Herold, M. Ziegler, K. Roth, D. Jacobowski, and M. D. Boettcher (1982)
JPEN J Parenter Enteral Nutr 6, 64-67
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Migration of Plasticizer From Hemodialysis Blood Tubing: Preliminary Report.
K. Ono, R. Tatsukawa, and T. Wakimoto (1975)
JAMA 234, 948-949
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Water Pollution: Organic Compounds in the Charles River, Boston.
R. A. Hites and K. Biemann (1972)
Science 178, 158-160
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Guidelines for Total Parenteral Nutrition.
M. E. Shils (1972)
JAMA 220, 1721-1729
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