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Science 23 October 1970:
Vol. 170. no. 3956, pp. 458 - 460
DOI: 10.1126/science.170.3956.458
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Articles

Rapid Axonal Transport of Sulfated Mucopolysaccharide Proteins

John S. Elam 1, Jack M. Goldberg 1, Norman S. Radin 1, and Bernard W. Agranoff 1

1 Mental Health Research Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor

When sulfur-35-labeled sodium sulfate is injected intraocularly in the goldfish, labeled sulfated mucopolysaccharides rapidly appear in the contra-lateral optic tectum of the brain, demonstrating the axonal flow of sulfated mucopolysaccharides. The transport rate is the same as that observed for proteins labeled after intraocular injection of tritiated proline. Treatment of the sulfur-35-labeled material with precipitants and enzymes reveals the presence of substances with properties similar to those of heparan sulfate (the major component) and chondroitin sulfate. Dermatan sulfate was not detected.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Axonal Transport of Tritium-Labeled Putrescine in the Embryonic Visual System of Zebrafish.
H. A. Fischer and E. Schmatolla (1972)
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Fast Transport of Materials in Mammalian Nerve Fibers.
S. Ochs (1972)
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