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Science 23 October 1970:
Vol. 170. no. 3956, pp. 454 - 455
DOI: 10.1126/science.170.3956.454
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Articles

Histamine Production by Transplantable Argyrophilic Gastric Carcinoid of Praomys (Mastomys) natalensis

Syun Hosoda 1, Wataru Nakamura 1, Katharine C. Snell 2, and Harold L. Stewart 2

1 Laboratory of Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
2 Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20014

A transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis contained appreciable amounts of histamine. Dialyzed, microsome-free supernatant of tumor tissue produced definite amounts of histamine in the presence of L-histidine and pyridoxal phosphate. These findings may relate to hypersecretion of gastric acid and formation of multiple ulcers in the stomach and duodenum of Mastomys bearing carcinoids.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)