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Science 16 October 1970:
Vol. 170. no. 3955, pp. 320 - 322
DOI: 10.1126/science.170.3955.320
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Articles

Chemically Induced Porphyria: Prevention by Prior Treatment with Phenobarbital

Leon Kaufman 1, Ann Louise Swanson 1, and Harvey S. Marver 1

1 Department of Medicine, University of California, San Francisco 94122

The excessive induction of hepatic dgr-aminolevulinic acid synthetase in rats after the administration of porphyria-inducing compounds is prevented by prior treatment with phenobarbital. Studies in vivo and in vitro indicate that phenobarbital prevents the induction of chemical porphyria by increasing the rate of detoxification of inducers by way of drug-metabolizing enzymes of the hepatic endoplasmic reticulum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Destruction of Cytochrome P450 by Secobarbital and Other Barbiturates Containing Allyl Groups.
W. Levin, E. Sernatinger, M. Jacobson, and R. Kuntzman (1972)
Science 176, 1341-1343
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Science. ISSN 0036-8075 (print), 1095-9203 (online)