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Science 9 October 1970:
Vol. 170. no. 3954, pp. 194 - 196
DOI: 10.1126/science.170.3954.194
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Articles

Harderian Gland: Influence on Pineal Hydroxyindole-O-Methyltransferase Activity in Neonatal Rats

Lennart Wetterberg 1, Arthur Yuwiler 1, Renee Ulrich 1, Edward Geller 1, and Raymond Wallace 1

1 Neurobiochemistry Laboratory, Veterans Administration Center and Department of Psychiatry, University of California School of Medicine, Los Angeles

A circadian rhythm has been found in hydroxyindole-O-methyltransferase activity of the pineal gland of blinded 12-day-old rats. Five additional hours of lighting can partly prevent the nocturnal increase in pineal hydroxyindole-O-methyltransferase activity in such rats. Removal of the Harderian gland abolishes this response to light in 12-day-old blinded animals, giving further support to the suggestion that this gland may function as an extraretinal photosensitive organ influencing the pineal gland in blinded suckling rats.


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