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Science 9 October 1970:
Vol. 170. no. 3954, pp. 181 - 183
DOI: 10.1126/science.170.3954.181
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Articles

Antitumor Activity in Mice of Tentacles of Two Tropical Sea Annelids

Frank L. Tabrah 1, Midori Kashiwagi 1, and Ted R. Norton 1

1 Department of Pharmacology, University of Hawaii School of Medicine, Honolulu 96816

Crude extracts of tentacles of two polychaetous annelids completely inhibit growth of Erlich ascites tumor in 60 to 100 percent of treated mice. Dialyzed extracts of one of these annelids, Lanice conchilega, show activity in the retentate after pronase digestion, suggesting that antitumor activity is associated with a nonprotein component of the crude tentacle extract.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Drugs from the sea.
G. Ruggieri (1976)
Science 194, 491-497
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Science. ISSN 0036-8075 (print), 1095-9203 (online)