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Science 2 October 1970:
Vol. 170. no. 3953, pp. 77 - 78
DOI: 10.1126/science.170.3953.77
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Articles

Intestinal Hydrolysis and Conjugation of a Pesticidal Carbamate in vitro

J. C. Pekas 1 and G. D. Paulson 1

1 Metabolism and Radiation Research Laboratory, Animal Science Research Division, Agricultural Research Service, Fargo, North Dakota 58102

The metabolite 1-[1-14C]naphthyl glucuronide was isolated from mucosal and serosal fluids of everted sacs of rat small intestine incubated in media containing either the insecticide 1-[1-14C]naphthyl N-methylcarbamate (carbaryl) or 1-[1-14C]naphthol. The hydrolysis of carbaryl and conjugation of the liberated naphthol indicated some degree of metabolism by the intestine before absorption.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)