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Science 2 October 1970:
Vol. 170. no. 3953, pp. 74 - 75
DOI: 10.1126/science.170.3953.74
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Articles

Genetically Controlled Total Deficiency of the Fourth Component of Complement in the Guinea Pig

Leonard Ellman 1, Ira Green 1, and Michael Frank 2

1 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014
2 Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases

Guinea pigs with a total deficiency of the fourth component of complement (C4) have been discovered. There was no evidence for the presence of a C4 inhibitor in the serum of these animals. Mating studies indicate that C4 deficiency is transmitted as a simple autosomal recessive trait. A colony of these animals is being established at the National Institutes of Health. They will provide an opportunity to more precisely define the role of complement in immune phenomena and the defense against disease.


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