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Science 25 September 1970:
Vol. 169. no. 3952, pp. 1326 - 1327
DOI: 10.1126/science.169.3952.1326
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Articles

Pregnancies after Chemotherapy of Trophoblastic Neoplasms

David H. Van Thiel 1, Griff T. Ross 1, and Mortimer B. Lipsett 1

1 National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

We have analyzed 88 pregnancies in 50 women who had previously been treated for gestational trophoblastic neoplasms with chemotherapeutic agents. No increase in fetal wastage, congenital abnormalities or complicated pregnancies was noted, suggesting that these drugs do not damage human oocytes in the doses and time periods used. The possibility that recessive mutations have been induced but were undetected cannot be evaluated definitively at present.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)