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Science 25 September 1970:
Vol. 169. no. 3952, pp. 1320 - 1321
DOI: 10.1126/science.169.3952.1320
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Articles

Prebiotic Synthesis of Propiolaldehyde and Nicotinamide

Michael J. Dowler 1, William D. Fuller 1, Leslie E. Orgel 1, and Robert A. Sanchez 1

1 Salk Institute of Biological Studies, San Diego, California 92112

We have identified propiololdehyde as a product of the action of an electric discharge on mixtures of methane and water or methane, nitrogen, and water. The aldehyde reacts with cyanoacetaldehyde and ammonia (other "prebiological molecules") to yield nicotinonitrile. This substance can be hydrolyzed to nicotinamide and nicotinic acid.


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F. Huang (2003)
Nucleic Acids Res. 31, e8
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Prebiotic synthesis from CO atmospheres: Implications for the origins of life.
S. Miyakawa, H. Yamanashi, K. Kobayashi, H. J. Cleaves, and S. L. Miller (2002)
PNAS 99, 14628-14631
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Prebiotic Synthesis of Methionine.
J. E. Van Trump and S. L. Miller (1972)
Science 178, 859-860
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Primitive Earth Synthesis of Nicotinic Acid Derivatives.
N. Friedmann, S. L. Miller, and R. A. Sanchez (1971)
Science 171, 1026-1027
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