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Science 11 September 1970:
Vol. 169. no. 3950, pp. 1099 - 1100
DOI: 10.1126/science.169.3950.1099
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Articles

Conversion of Thyroxine to Triiodothyronine in Normal Human Subjects

Kenneth Sterling 1, Milton A. Brenner 1, and Edward S. Newman 1

1 Protein Research Laboratory and Veterans Administration Hospital, Bronx, New York 10468, and Department of Pathology, Columbia University College of Physicians and Surgeons, New York 10032

The conversion of thyroxine to triiodothyronine, previously demonstrated in athyreotic human subjects, has been investigated in normal subjects who were given intravenous injections of purified thyroxine labeled with carbon-14 in ring A and in the alanine side chain. Evidence for the conversion of T4 to T3 was provided by the finding of carbon-14 in the T3 fraction isolated from serums. It is estimated that an appreciable fraction of T4 may be transformed to T3 in normal man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thyroid hormone action: the mitochondrial pathway.
K Sterling, P. Milch, M. Brenner, and J. Lazarus (1977)
Science 197, 996-999
   Abstract »    PDF »
Liothyronine Treatment in Psychotic and Nonpsychotic Children Under 6 Years.
M. Campbell, B. Fish, R. David, T. Shapiro, P. Collins, and C. Koh (1973)
Arch Gen Psychiatry 29, 602-608
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Conversion of Thyroxine to Triiodothyronine by Cultured Human Cells.
K. Sterling, M. A. Brenner, and V. F. Saldanha (1973)
Science 179, 1000-1001
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Acute Metabolic Responses in Myxedema to Large Doses of Intravenous L-Thyroxine.
E. C. RIDGWAY, J. A. McCAMMON, J. BENOTTI, and F. MALOOF (1972)
Ann Intern Med 77, 549-555
   Abstract »    PDF »
Triiodothyronine: The 3'-Iodine Is Proximal to the agr-Ring in Crystal Structure Conformation.
N. Camerman and A. Camerman (1972)
Science 175, 764-766
   Abstract »    PDF »
Thyroxine: Conversion to Triiodothyronine by Isolated Perfused Rat Heart.
J. L. Rabinowitz and E. S. Hercker (1971)
Science 173, 1242-1243
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