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Science 11 September 1970:
Vol. 169. no. 3950, pp. 1095 - 1097
DOI: 10.1126/science.169.3950.1095
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Articles

Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes

Seymour J. Klebanoff 1

1 U.S. Public Health Service Hospital, Seattle, Washington 98114, and Department of Medicine, University of Washington School of Medicine, Seattle 98105

Azide and, to a lesser extent, cyanide inhibit the microbicidal activity of myeloperoxidase and of intact normal leukocytes, but they have little or no effect on peroxidase-negative leukocytes. The contribution of the azide-sensitive (peroxidase-dependent?) systems to the total microbicidal activity of normal leukocytes is considerable. The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocytes than in normal leukocytes, thus suggesting an adaptation.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)