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Science 11 September 1970:
Vol. 169. no. 3950, p. 1087
DOI: 10.1126/science.169.3950.1087
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Articles

Oxychlordane, Animal Metabolite of Chlordane: Isolation and Synthesis

Bruce Schwemmer 1, William P. Cochrane 2, and Percy B. Polen 3

1 Research and Development Department, Velsicol Chemical Corporation, 341 East Ohio Street, Chicago, Illinois 60611
2 Canada Department of Agriculture, Production and Marketing Branch, Plant Products Building, Ottawa
3 Research and Development Department, Velsicol Chemical Corporation

Oxychlordane (C10H4Cl8O), a minor heretofore unidentified metabolite, was isolated from fat of pigs on diets heavily dosed with pure isomers of the insecticide, chlordane (C10H6Cl8). Chemical and spectroscopic evidence provides bases for proposal of structure of the metabolite as 1-exo-2-endo-4,5,6,7,8,8-octachloro-2,3-exo-epoxy-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)