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Science 28 August 1970:
Vol. 169. no. 3948, pp. 882 - 883
DOI: 10.1126/science.169.3948.882
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Articles

Pathways through Networks of Branched DNA

O. Smithies 1

1 Laboratory of Genetics, University of Wisconsin, Madison 53706

Differentiation may be controlled by forks in DNA each having a replicatable protein "switch," stable in either a "left" or a "right" configuration, which determines the path through the DNA network taken by RNA polymerases during transcription. The possibility for dedifferentiation exists, but differentiation could be made irreversible by the exertion of a similar control over parts of the paths through the network taken by DNA polymerases. The concept of bistable switches at DNA branch points can be used to account for antibody variability.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antibody Wars: Extreme Diversity.
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J. Immunol. 177, 4235-4236
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V-region Genes for Rabbit Ig Heavy Chains.
K. L. Knight, W. J. Horng, and S. Dray (1977)
Cold Spring Harb Symp Quant Biol 41, 687-688
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The Rolling Helix: A Model for the Eukaryotic Gene?.
C. A. Thomas Jr. (1974)
Cold Spring Harb Symp Quant Biol 38, 347-352
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Immunoglobulin Genes: Arranged in Tandem or in Parallel?.
O. Smithies (1974)
Cold Spring Harb Symp Quant Biol 38, 725-737
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Molecular Defect in a Gamma-2 (ggr2) Heavy Chain.
S. M. Cooper, E. C. Franklin, and B. Frangione (1972)
Science 176, 187-189
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Deletions in Immunoglobulin Polypeptide Chains as Evidence for Breakage and Repair in DNA.
O. Smithies, D. M. Gibson, E. M. Fanning, M. E. Percy, D. M. Parr, and G. E. Connell (1971)
Science 172, 574-577
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