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Science 21 August 1970:
Vol. 169. no. 3947, pp. 773 - 775
DOI: 10.1126/science.169.3947.773
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Articles

Biosynthesis of Vitamin B6: Incorporation of Three-Carbon Units

Robert E. Hill 1 and Ian D. Spenser 1

1 Department of Chemistry, McMaster University, Hamilton, Ontario, Canada

Pyridoxol, one of the forms of vitamin B6, is derived from three glycerol units. One of these is incorporated by way of pyruvate as a two-carbon fragment at the oxidation level of acetaldehyde. The other two glycerol units are incorporated intact, possibly by way of triose phosphate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Extremely Conserved pyroA Gene of Aspergillus nidulans Is Required for Pyridoxine Synthesis and Is Required Indirectly for Resistance to Photosensitizers.
A. H. Osmani, G. S. May, and S. A. Osmani (1999)
J. Biol. Chem. 274, 23565-23569
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The Biogenetic Anatomy of Vitamin B6. A 13C NMR INVESTIGATION OF THE BIOSYNTHESIS OF PYRIDOXOL IN ESCHERICHIA COLI.
R. E. Hill, K. Himmeldirk, I. A. Kennedy, R. M. Pauloski, B. G. Sayer, E. Wolf, and I. D. Spenser (1996)
J. Biol. Chem. 271, 30426-30435
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