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Science 14 August 1970:
Vol. 169. no. 3946, pp. 688 - 689
DOI: 10.1126/science.169.3946.688
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Articles

Lesch-Nyhan Syndrome: Preventive Control by Prenatal Diagnosis

J. A. Boyle 1, K. O. Raivio 1, K. H. Astrin 2, J. D. Schulman 3, M. L. Graf 4, J. E. Seegmiller 4, and C. B. Jacobsen 5

1 Department of Medicine, School of Medicine, University of California, San Diego, La Jolla 92037
2 Department of Biology, University of California, San Diego
3 National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland
4 Department of Medicine, School of Medicine, University of California, San Diego
5 Department of Obstetrics and Gynecology, George Washington University, Washington, D.C.

The Lesch-Nyhan syndrome was detected in a fetus at a time sufficiently early to allow termination of the pregnancy. The feasibility of a preventive program for control of a severe sex-linked neurological disease through prenatal diagnosis is thus demonstrated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
New Prospects for Understanding and Control of Genetic Diseases.
J. E. Seegmiller (1972)
Arch Intern Med 130, 181-185
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An Approach to the Control of PRT Deficiency Through Antenatal Diagnosis.
W. Y. Fujimoto (1972)
Arch Intern Med 130, 207-211
   Abstract »    PDF »
Inborn Terror of Metabolism.
S. V. (1970)
JAMA 214, 2186-2187
   Abstract »    PDF »


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