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Science 7 August 1970:
Vol. 169. no. 3945, pp. 611 - 612
DOI: 10.1126/science.169.3945.611
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Articles

Chemical Basis of Hashish Activity

Raphael Mechoulam 1, Arnon Shani 1, Habib Edery 2, and Yona Grunfeld 2

1 Laboratory of Natural Products, Hebrew University Pharmacy School, Jerusalem, Israel
2 Israel Institute for Biological Research, Ness Ziona, and Tel Aviv University Medical School, Tel Aviv, Israel

A sample of hashish was extracted consecutively with petroleum ether, benzene, and methanol. When tested intravenously in monkeys only the petroleum-ether fraction was active. This material was further fractionated. The only active compound isolated was Dgr1-tetrahydrocannabinol. Cannabinol, cannabidiol, cannabichromene, cannabigerol, and cannabicyclol when administered together with Dgr1-tetrahydrocannabinol do not cause a change in the activity of the latter, under the experimental conditions used. These results provide evidence that, except for Dgr1-tetrahydrocannabinol, no other major, psychotomimetically active compounds are present in hashish.


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