Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 31 July 1970:
Vol. 169. no. 3944, pp. 495 - 497
DOI: 10.1126/science.169.3944.495
Prev | Table of Contents | Next

Articles

Chromosomal Abnormalities in the Human Population: Estimation of Rates Based on New Haven Newborn Study

H. A. Lubs 1 and F. H. Ruddle 2

1 Department of Pediatrics, University of Colorado Medical Center, Denver 80220
2 Department of Biology, Yale University, New Haven, Connecticut

The incidence of gross chromosomal abnormality was measured in a large (4500), relatively unbiased sample of New Haven infants born during 1 year. The frequency of infants with abnormal chromosomal constitutions was 0.5 percent. For mothers over age 34, 1.5 percent of newborns were chromosomally abnormal. Only one in four of these infants could have been detected by phenotypic criteria alone. Methods are discussed whereby this fraction of the newborn population might be detected and possibly reduced.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Update in Andrology.
D. J. Handelsman (2007)
J. Clin. Endocrinol. Metab. 92, 4505-4511
   Abstract »    Full Text »    PDF »
Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.
D. Wells and J. D.A. Delhanty (2000)
Mol. Hum. Reprod. 6, 1055-1062
   Abstract »    Full Text »    PDF »
Variability in the Y Chromosome and Variability of Human Behavior.
E. Dorus (1980)
Arch Gen Psychiatry 37, 587-594
   Abstract »    PDF »
Prenatal Diagnosis of Double Trisomy.
L. Y.F. Hsu, L. Strauss, A. V. Alter, H. J. Kim, and K. Hirschhorn (1975)
Arch Pediatr Adolesc Med 129, 381-382
   Abstract »    PDF »
Prenatal Diagnosis of Genetic Disorders: An Analysis of Experience With 600 Cases.
A. Milunsky and L. Atkins (1974)
JAMA 230, 232-235
   Abstract »    PDF »
Prenatal Diagnosis of Trisomy 18: Pathologic Findings in 20-Week Conceptus.
L. Y. F. Hsu, L. Strauss, E. Dubin, and K. Hirschhorn (1973)
Arch Pediatr Adolesc Med 125, 290-292
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)