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Science 31 July 1970:
Vol. 169. no. 3944, pp. 490 - 491
DOI: 10.1126/science.169.3944.490
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Articles

Cyclic Adenosine Monophosphate: Potassium-Dependent Action on Vascular Smooth Muscle Membrane Potential

Avril V. Somlyo 1, G. Haeusler 2, and A. P. Somlyo 3

1 Presbyterian-University of Pennsylvania Medical Center, Philadelphia 19104
2 F. Hoffmann-La Roche and Co., Basel, Switzerland
3 Department of Pathology, University of Pennsylvania School of Medicine and Presbyterian-University of Pennsylvania Medical Center, Philadelphia 19104

Dibutyryl cyclic adenosine monophosphate and theophylline hyperpolarize smooth muscle of rabbit main pulmonary artery in low concentrations of potassium (1 millimole per liter) but do not have a significant effect on the membrane potential in the presence of high concentrations of potassium (10 millimoles per liter). The dependence of the hyperpolarizing effect on a low external concentration of potassium is similar to that observed with isoproterenol. Prior treatment with theophylline potentiated the hyperpolarizing action of isoproterenol. These findings are compatible with the assumption that potassium-dependent, beta-adrenergic hyperpolarization is mediated by cyclic adenosine monophosphate.


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