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Science 31 July 1970:
Vol. 169. no. 3944, pp. 485 - 487
DOI: 10.1126/science.169.3944.485
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Articles

Fetal Kidney in Organ Culture: Abnormalities of Development Induced by Decreased Amounts of Potassium

John F. S. Crocker 1 and R. L. Vernier 1

1 Department of Pediatrics, University of Minnesota Hospitals, Minneapolis 55455

Kidneys from fetal mice (10 to 18 days' gestation) were grown in organ culture. Concentrations of potassium less than 9 milliequivalents per liter (10- to 14-day kidneys), and less than 6 milliequivalents per liter (14- to 18-day kidneys), produced abnormal branching, failure of nephron induction, and occasional cystic dilatations of the ureteral bud. These studies emphasize the importance of an environment with a high concentration of potassium for development of the fetal kidney.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In Utero and in Vitro Exposure to {beta}-Lactams Impair Kidney Development in the Rat.
S. NATHANSON, E. MOREAU, C. MERLET-BENICHOU, and T. GILBERT (2000)
J. Am. Soc. Nephrol. 11, 874-884
   Abstract »    Full Text »
Human Embryonic Kidneys in Organ Culture: Abnormalities of Development Induced by Decreased Potassium.
J. F. S. Crocker (1973)
Science 181, 1178-1179
   Abstract »    PDF »


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