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Science 24 July 1970:
Vol. 169. no. 3943, pp. 387 - 388
DOI: 10.1126/science.169.3943.387
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Articles

Divergent Biological Effects of Adenosine and Dibutyryl Adenosine 3',5'-Monophosphate on the Isolated Fat Cell

Solomon S. Solomon 1, James S. Brush 1, and Abbas E. Kitabchi 1

1 Laboratories of Endocrinology and Metabolism, Veterans Administration Hospital, and Departments of Biochemistry and Medicine, University of Tennessee, Memphis 38104

Adenosine 3',5'-monophosphate stimulated production of carbon dioxide and lipid from glucose, whereas its dibutyryl derivative inhibited this conversion. Addition of the dibutyryl derivative to the isolated fat cell further stimulated lipolysis induced by adrenocorticotropic hormone, whereas addition of adenosine 3',5'-monophosphate inhibited this lipolysis. Hence, measured by these two parameters, the biologic properties of adenosine 3',5'-monophosphate and its dibutyryl derivative are distinctly different.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Modulation of Adenylate Cyclase Activity in Liver and Fat Cell Membranes by Insulin.
G. Illiano and P. Cuatrecasas (1972)
Science 175, 906-908
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