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Science 17 July 1970:
Vol. 169. no. 3942, pp. 291 - 293
DOI: 10.1126/science.169.3942.291
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Articles

Bone Marrow Histogenesis: A Comparison of Fatty and Red Marrow

Mehdi Tavassoli 1 and William H. Crosby 1

1 Blood Research Laboratory, Tufts-New England Medical Center, Boston, Massachusetts 02111

Histogenesis of fatty marrow in extramedullary sites was compared to histogenesis of the red marrow. Both tissues undergo a similar sequence of events leading to reconstruction of hemopoietic marrow nodules. Histogenesis of yellow marrow then continues; such implants become nodules of fatty marrow, whereas implants of red marrow remain hemopoietically active. This observation supports the concept that histogenesis of the bone marrow recapitulates the ontogeny of this organ and indicates an intrinsic difference between the stroma of red and yellow marrow.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Murine Bone Marrow Stromally Derived BMS2 Adipocytes Support Differentiation and Function of Osteoclast-Like Cells in Vitro.
K. A. Kelly, S. Tanaka, R. Baron, and J. M. Gimble (1998)
Endocrinology 139, 2092-2101
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