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Science 17 July 1970:
Vol. 169. no. 3942, pp. 284 - 285
DOI: 10.1126/science.169.3942.284
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Articles

In vitro Lymphocyte Reactivity during Depression of Tuberculin Hypersensitivity by 6-Mercaptopurine

Burton Zweiman 1 and S. Michael Phillips 2

1 Department of Medicine, University of Pennsylvania, Philadelphia 19104
2 Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts 02115

Administration of 6-mercaptopurine suppressed appearance of tuberculin skin test reactivity for up to 6 weeks after mycobacterial injection. Lymphocytes obtained during the period of suppressed tuberculin reactivity exhibited normal in vitro proliferative responses to tuberculin, suggesting that the drug may not be qualitatively affecting function of immunologically competent cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytotoxic Drugs in Treatment of Nonmalignant Diseases.
A. D. STEINBERG, P. H. PLOTZ, S. M. WOLFF, V. G. WONG, S. G. AGUS, and J. L. DECKER (1972)
Ann Intern Med 76, 619-642
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