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Science 10 July 1970:
Vol. 169. no. 3941, pp. 198 - 201
DOI: 10.1126/science.169.3941.198
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Articles

Acetylsalicylic Acid: No Chromosome Damage in Human Leukocytes

Irving Mauer 1, David Weinstein 1, and Harvey M. Solomon 2

1 Cytogenetics Group, Department of Experimental Pathology and Toxicology, Hoffman-La Roche Inc., Nutley, New Jersey 07110
2 Hoffmann-La Roche Special Treatment Unit, Martland Hospital, Newark, New Jersey 07110

Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). Leukocytes were also cultured from human volunteers during the ingestion of two 300-milligram tablets four times daily (2400 milligrams per day) over a 1-month period. No significant increase in chromosome aberrations was detected in vitro or in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
LSD and Genetic Damage.
N. I. Dishotsky, W. D. Loughman, R. E. Mogar, and W. R. Lipscomb (1971)
Science 172, 431-440
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