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Science 3 July 1970:
Vol. 169. no. 3940, pp. 89 - 91
DOI: 10.1126/science.169.3940.89
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Articles

Drug Effect Prediction by Computer

Eugene E. Gloye 1 and Rudolph J. Marcus 1

1 Office of Naval Research, 1030 East Green Street, Pasadena, California 91101

The mass of information available about effects of chemical substances (drugs) on behavioral, biochemical, and physiological systems of living organisms is so extensive as to defy traditional methods of analysis. A procedure that provides automated, computerized searches for patterns among these effects has been developed and has been applied to a data base constructed of medical and chemical information from The Merck Index. One promising result is the development of new hypotheses about mechanisms of drug action.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)