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Science 3 July 1970:
Vol. 169. no. 3940, pp. 76 - 78
DOI: 10.1126/science.169.3940.76
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Articles

Ontogeny of the Estrogen Receptor during Early Uterine Development

James H. Clark 1 and Jack Gorski 1

1 Department of Physiology and Biophysics, University of Illinois, Urbana

The number of estrogen binding sites in uterine cytoplasm on a per cell basis reaches a maximum by day 10 of life in both intact and castrate female rats. After this peak is reached, the number of binding sites per cell decreases, and the ratio remains constant until days 22 to 23 of life. Thus, the ontogeny of the estrogen binding protein is not dependent upon estrogen from the ovary and is probably an autonomous property of uterine cells. Sedimentation values and dissociation constants of the protein when the animals are 5 to 10 days of age are similar to those of the 22-day-old animal, indicating that the same protein is present throughout postnatal development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genome-Wide Identification of High-Affinity Estrogen Response Elements in Human and Mouse.
V. Bourdeau, J. Deschenes, R. Metivier, Y. Nagai, D. Nguyen, N. Bretschneider, F. Gannon, J. H. White, and S. Mader (2004)
Mol. Endocrinol. 18, 1411-1427
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Developmental Biology of Uterine Glands.
C. A. Gray, F. F. Bartol, B. J. Tarleton, A. A. Wiley, G. A. Johnson, F. W. Bazer, and T. E. Spencer (2001)
Biol Reprod 65, 1311-1323
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Tissue-Specific Expression of Messenger Ribonucleic Acids for Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins during Perinatal Development of the Rat Uterus.
Y. Gu, W.S. Branham, D.M. Sheehan, P.J. Webb, C.L. Moland, and R.D. Streck (1999)
Biol Reprod 60, 1172-1182
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Clomid or nafoxidine administered to neonatal rats causes reproductive tract abnormalities.
J. Clark and S McCormack (1977)
Science 197, 164-165
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Steroid Receptors and Hormone Receptivity: New Approaches in Pharmacology and Therapeutics.
E.-E. Baulieu (1975)
JAMA 234, 404-409
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