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Science 5 June 1970:
Vol. 168. no. 3936, pp. 1228 - 1229
DOI: 10.1126/science.168.3936.1228
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Articles

utri1-Tetrahydrocannabinol: Structure of a Major Metabolite

I. M. Nilsson 1, S. Agurell 1, J. L. G. Nilsson 1, A. Ohlsson 1, F. Sandberg 1, and M. Wahlqvist 1

1 Faculty of Pharmacy, Box 6804, 113 86 Stockholm, and Military Pharmacy, Karolinska Sjukhuset, 104 01 Stockholm, Sweden

utri1-Tetrahydrocannabinol, the major psychotomimetically active compound of Cannabis, was metabolized in vitro by the 10, OOOg supernatant from rabbit liver. By mass and nuclear magnetic resonance spectrometry, the major metabolite was identified as 7-hydroxy-utri1-tetrahydrocannabinol. The latter compound of Cannabis, was metabolized in vitro by the 10,OOOg supernatant from


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. H. K. Liu and A. C. Dacus (1987)
Arch Ophthalmol 105, 245-248
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Isolation and Characterization of Two Major Urinary Metabolites of Dgr1-Tetrahydrocannabinol.
S. Burstein, J. Rosenfeld, and T. Wittstruck (1972)
Science 176, 422-423
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Activity of Dgr8-and Dgr9-Tetrahydrocannabinol and Related Compounds in the Mouse.
H. D. Christensen, R. I. Freudenthal, J. T. Gidley, R. Rosenfeld, G. Boegli, L. Testino, D. R. Brine, C. G. Pitt, and M. E. Wall (1971)
Science 172, 165-167
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Marihuana in Man: Three Years Later.
L. E. Hollister (1971)
Science 172, 21-29
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