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Science 29 May 1970:
Vol. 168. no. 3935, pp. 1091 - 1092
DOI: 10.1126/science.168.3935.1091
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Articles

Solution Conformation of Valinomycin-Potassium Ion Complex

M. Ohnishi 1 and D. W. Urry 1

1 Institute for Biomedical Research, Education and Research Foundation, American Medical Association, 535 North Dearborn, Chicago, Illinois 60610

The complete conformation of the valinomycin-potassium ion complex in methanol is presented. Extension from the reported secondary structure requires arguments and data relating to ester orientation, direction of coiling, side-chain orientation, and conformational stability. Conformation of the valinomycin-potassium ion complex provides a clear-cut example in which elucidation of conformation is sufficient to gain an understanding of molecular function which, in this case, is selective ion transport by a carrier mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Carrier-Mediated Ion Transport: Electrical relaxation experiments give insight into the kinetics of ion transport through artificial lipid membrane.
P. Lauger (1972)
Science 178, 24-30
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Valinomycin Crystal Structure Determination by Direct Methods.
W. L. Duax, H. Hauptman, C. M. Weeks, and D. A. Norton (1972)
Science 176, 911-914
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Science. ISSN 0036-8075 (print), 1095-9203 (online)