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Science 22 May 1970:
Vol. 168. no. 3934, pp. 998 - 1000
DOI: 10.1126/science.168.3934.998
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Articles

Colicin-Tolerant Mutants of Escherichia coli: Resistance of Membranes to Colicin El

Pinakilal Bhattacharyya 1, Louis Wendt 1, Eleanor Whitney 1, and Simon Silver 1

1 Department of Biology, Washington University, St. Louis, Missouri 63130

Colicin E1 blocks proline accumulation by membrane vesicles prepared from wild-type sensitive Escherichia coli. Two classes of mutant cells are unaffected by colicin. Vesicles from colicin-resistant strains are sensitive to colicin E1, whereas vesicles from colicin-tolerant strains are unaffected by colicin El. These results suggest that the colicin E1 receptor is on the cell membrane and that colicin-tolerant strains have altered membranes while colicin-resistant strains have altered cell walls.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)