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Science 15 May 1970:
Vol. 168. no. 3933, pp. 864 - 866
DOI: 10.1126/science.168.3933.864
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Articles

Teratogenic Evaluation of 2,4,5-T

K. Diane Courtney 1, D. W. Gaylor 1, M. D. Hogan 1, H. L. Falk 1, R. R. Bates 2, and I. Mitchell 2

1 National Institute of Environmental Health Sciences, National Institutes of Health, P. O. Box 12233, Research Triangle Park, North Carolina 27709
2 National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

The herbicide 2,4,5-trichlorophenoxyacetic acid is teratogenic and fetocidal in two strains of mice when administered either subcutaneously or orally and in one strain of rats when administered orally. The incidences of both cystic kidney and cleft palate were increased in the C57BL/6 mice as well as the incidence of cleft palate in the AKR mice. The incidence of cystic kidney was also increased in the rats. In addition, an increase in the ratio of liver weight to body weight in the mouse fetus and the occurrence of hemorrhagic gastrointestinal tract in the rat fetus suggest that this compound also has fetotoxic properties.


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