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Science 15 May 1970:
Vol. 168. no. 3933, pp. 861 - 862
DOI: 10.1126/science.168.3933.861
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Articles

Orotidinuria Induced by Allopurinol

R. M. Fox 1, D. Royse-Smith 1, and W. J. O'Sullivan 1

1 Department of Medicine, University of Sydney, Sydney, New South Wales 2006

The administration of allopurinol to patients suffering from hyperuricemia and to normal subjects results in increased excretion of the pyrimidine nucleoside orotidine. Evidence is presented for the interference by allopurinol of the de novo biosynthesis of uridine 5'-phosphate in man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Development of Allopurinol.
R. W. Rundles (1985)
Arch Intern Med 145, 1492-1503
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Allopurinol and Cytotoxic Drugs: Interaction in Relation to Bone Marrow Depression.
Boston Collaborative Drug Surveillance Program (1974)
JAMA 227, 1036-1040
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Phosphoribosylpyrophosphate in Man: Biochemical and Clinical Significance.
I. H. FOX and W. N. KELLEY (1971)
Ann Intern Med 74, 424-433
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