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Science 15 May 1970:
Vol. 168. no. 3933, pp. 854 - 856
DOI: 10.1126/science.168.3933.854
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Articles

Catecholamine Biosynthesis in Brains of Rats Treated with Morphine

Doris H. Clouet 1 and Milton Ratner 1

1 New York State Research Institute for Neurochemistry and Drug Addiction, Ward's Island, New York 10035

In the brains of rats without tolerance to morphine, the accumulation of [14C]dopamine formed from [14C]tyrosine injected intracisternally is increased, reaching a maximum in the hypothalamus and striatum 1 hour after administration of morphine. In tolerant rats, the rate of incorporation of carbon-14 into dopamine and into norepinephrine in these areas is more than twice that in animals that have received only one injection of morphine.


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