Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 May 1970:
Vol. 168. no. 3933, pp. 852 - 854
DOI: 10.1126/science.168.3933.852
Prev | Table of Contents | Next

Articles

Immune Responses of Inbred Mice to Repeated Low Doses of Antigen: Relationship to Histocompatibility (H-2) Type

Nelson M. Vaz 1 and Bernard B. Levine 1

1 Department of Medicine, New York University School of Medicine, New York 10016

Immunization of inbred strains of mice with repeated minute doses (0.1 to 1.0 microgram) of hapten-protein conjugates demonstrated wide differences in the magnitude of their antibody responses, which were related to the histocompatibility (H-2) type of the strains. Immunization with a single high dose (100 micrograms) of antigen failed to demonstrate these differences.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunogenicity of Bacillus anthracis Protective Antigen Domains and Efficacy of Elicited Antibody Responses Depend on Host Genetic Background.
N. Abboud and A. Casadevall (2008)
Clin. Vaccine Immunol. 15, 1115-1123
   Abstract »    Full Text »    PDF »
Effect of Low-Dose Antigen Exposure on Development of Immunity to Helicobacter pylori Infection in Mice.
F. J. Radcliff and R. L. Ferrero (2001)
Infect. Immun. 69, 5186-5188
   Abstract »    Full Text »    PDF »
Genetic Variability in Pulmonary Physiological, Cellular, and Antibody Responses to Antigen in Mice.
J. P. BREWER, A. B. KISSELGOF, and T. R. MARTIN (1999)
Am. J. Respir. Crit. Care Med. 160, 1150-1156
   Abstract »    Full Text »
A Familial Occurrence of Allergic Bronchopulmonary Aspergillosis.
T. S. GRAVES, J. N. FINK, R. PATTERSON, V. P. KURUP, and G. T. SCANLON (1979)
Ann Intern Med 91, 378-382
   Abstract »    PDF »
Association of the HL-A7 Cross-Reacting Group with a Specific Reaginic Antibody Response in Allergic Man.
D. G. Marsh, W. B. Bias, S. H. Hsu, and L. Goodfriend (1973)
Science 179, 691-693
   Abstract »    PDF »
Ragweed Hay Fever: Genetic Control and Linkage to HL-A Haplotypes.
B. B. Levine, R. H. Stember, and M. Fotino (1972)
Science 178, 1201-1203
   Abstract »    PDF »
Histocompatibility-Linked Immune Response Genes.
B. Benacerraf and H. O. McDevitt (1972)
Science 175, 273-279
   PDF »
Autoimmune Murine Thyroiditis Relation to Histocompatibility (H-2) Type.
A. O. Vladutiu and N. R. Rose (1971)
Science 174, 1137-1139
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)