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Science 1 May 1970:
Vol. 168. no. 3931, p. 582
DOI: 10.1126/science.168.3931.582
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Articles

DDT Metabolism: Oxidation of the Metabolite 2,2-bis(p-Chlorophenyl) ethanol by Alcohol Dehydrogenase

Joseph E. Suggs 1, Robert E. Hawk 1, August Curley 1, Elizabeth L. Boozer 1, and James D. McKinney 2

1 Atlanta Toxicology Branch, Division of Pesticides, Bureau of Science, Food and Drug Administration, Atlanta, Georgia 30333
2 National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

A metabolite of DDT, 2,2-bis(p-chlorophenyl)ethanol, is a substrate of crystalline liver alcohol dehydrogenase. The oxidation of the substrate was detected spectrophotometrically. The p-nitrophenylhydrazone derivative of the product, 2,2-bis(p-chlorophenyl)acetaldehyde, was identified by comparing its mass spectrum and thin-layer chromatographic behavior with that of an authentic sample.


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