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Science 17 April 1970:
Vol. 168. no. 3929, pp. 373 - 374
DOI: 10.1126/science.168.3929.373
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Articles

1, 3-Bis(p-chlorobenzylideneamino)guanidine Hydrochloride (Robenzidene): New Poultry Anticoccidial Agent

Sidney Kantor 1, Robert L. Kennett Jr. 1, Emanuel Waletzky 1, and Andrew S. Tomcufcik 2

1 Agricultural Division, American Cyanamid Company, P. O. Box 400, Princeton, New Jersey 08540
2 Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York 10965

At 66 parts per million in the feed, robenzidene is highly effective in preventing chicken coccidiosis caused by any one of eight Eimeria species. Three times this dose is safe for broiler chickens. In dogs and rats, the toxicity was relatively low over a period of 90 days. In laboratory trials, the drug completely prevents oocyst production by seven species and greatly reduces oocyst production by Eimeria maxima.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)