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Science 17 April 1970:
Vol. 168. no. 3929, pp. 370 - 372
DOI: 10.1126/science.168.3929.370
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Articles

Isoantigenic Variants: Isolation from Human Diploid Cells in Culture

R. Adman 1 and D. A. Pious 1

1 Department of Pediatrics, University of Washington School of Medicine, Seattle 98105

Variant human fibroblast substrains, resistant to a cytotoxic human isoantiserum, were isolated from sensitive strains by repeated exposure to isoantiserum and rabbit complement. The resistant phenotype was stable, apparently occurred at low frequency, and was associated with loss of surface isoantigens.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)