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Science 10 April 1970:
Vol. 168. no. 3928, pp. 253 - 255
DOI: 10.1126/science.168.3928.253
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Articles

Steroid Hormones: Effects on Adenyl Cyclase Activity and Adenosine 3',5'-Monophosphate in Target Tissues

M. G. Rosenfeild 1 and B. W. O'Malley 1

1 Natiolnal Cancer institute. Bethesda, Maryland 20014, and Vanderbilt University School of Medicine, Nashville, Tennessee

The adenyl cyclases of chick oviduct and rat prostate were not stimulated by estrogen and testosterone, respectively, suggesting that growth and differentiation of these target tissues are not mediated by adenosine 3',5'-monophosphate. Estrogen acutely activated adenyl cyclase in the castrate rat uterus, but this was prevented by administration of DL-propranolol, suggesting that the effect was mediated by catecholamines. Progesterone produced a delayed stimulation of oviduct adenyl cyclase preceding and concomitant with the induction of synthesis of avidin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phosphorylated proteins as physiological effectors.
P Greengard (1978)
Science 199, 146-152
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