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Science 3 April 1970:
Vol. 168. no. 3927, pp. 135 - 138
DOI: 10.1126/science.168.3927.135
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Articles

Mitochondrial RNA Synthesis during Mitosis

Hung Fan 1 and Sheldon Penman 1

1 Department of Biology, Massachlusetts Institute of Technology, Cambridge

HeLa cells arrested in metaphase synthesized relatively normal amounts of mitochondrial RNA, while little RNA synthesis associated with the nucleus was detected. The RNA synthesized resembled the portion of mitochondrial RNA sensitive to ethidium bromide in interphase cells, with major peaks at 21, 12, and 4S. Unlike that in interphase cells, RNA synthesis in the mitoclhonidrial fraction of mitotic cells was completely inhibited by ethidium bromide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Prologue to the Study of the Nonhistone Chromosomal Proteins.
S. C. R. Elgin, J. B. Boyd, L. E. Hood, W. Wray, and F. C. Wu (1974)
Cold Spring Harb Symp Quant Biol 38, 821-833
   Abstract »    PDF »
Synthesis of 5S and 4S RNA in Metaphase-Arrested HeLa Cells.
E. A. Zylber and S. Penman (1971)
Science 172, 947-949
   Abstract »    PDF »
Distinct RNA Synthesis Systems of the HeLa Cell.
S. Penman, H. Fan, S. Perlman, M. Rosbash, R. Weinberg, and E. Zylber (1970)
Cold Spring Harb Symp Quant Biol 35, 561-575
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)