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Science 27 March 1970:
Vol. 167. no. 3926, pp. 1749 - 1751
DOI: 10.1126/science.167.3926.1749
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Articles

Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism

Gerald Cohen 1 and Michael Collins 1

1 Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York 10032

Epinephrine and norepinephrine condensed with acetaldehyde or with formaldehyde in dilute aqueous solution at neutral pH and room temperature to form 1,2,3,4-tetrahydroiso-quinoline alkaloids. Similar condensation reactions occurred in cow adrenal glands perfused with dilute aldehyde solutions at 37°C. Biosynthesis of these alkaloids in vivo could play a role in altering an individual's behavior during and after the ingestion of alcohol.


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Naloxone and Alcohol Intoxication in the Dog.
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Dopamine-related tetrahydroisoquinolines: significant urinary excretion by alcoholics after alcohol consumption.
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Morphine and Ethanol: Selective Depletion of Regional Brain Calcium.
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Ethanol Preference in the Rat as a Function of Photoperiod.
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Induction of Liver Acetaldehyde Dehydrogenase: Possible Role in Ethanol Tolerance after Exposure to Barbiturates.
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Blood Concentrations of Acetaldehyde and Ethanol in Chronic Alcoholics.
E. Majchrowicz and J. H. Mendelson (1970)
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