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Science 27 March 1970:
Vol. 167. no. 3926, pp. 1727 - 1729
DOI: 10.1126/science.167.3926.1727
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Articles

Spontaneous Rhythmic Contraction of Separated Heart Muscle Cells

Sherman Bloom 1

1 Department of Pathology, University of Utah College of Medicine, Salt Lake City 84112

Muscle cells that conitract spontaneously and rhythmically can be obtained from adult mouse myocardium. Contractions are observed immediately after homogenization in a solution that is ionically similar to intracellular fluid. Contraction frequency varies directly with temperature and decreases as a function of time after homogenization. At 16°C rhythmic relaxation and contraction occur for about 20 minutes. Contractions are dependent on the presence of adenosine triphosphate in the homogenization medium.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)