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Science 20 March 1970:
Vol. 167. no. 3925, pp. 1629 - 1631
DOI: 10.1126/science.167.3925.1629
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Articles

DNA Synthesis in the Anterior Pituitary of the Male Rat: Effect of Castration and Photoperiod

W. C. Hymer 1, Andrea Mastro 1, and Elaine Griswold 1

1 Biolovy Department, Pennsylvania State University, University Park 16802

Castration increased incorporation of tritiated thymidine into total DNA in the anterior pituitary gland. Furthermore, there was a threefold increase in the percentage of labeled basophils 1 month after castration. Exposure of rats to constant light or dark also changed DNA synthesis; these changes depended on age of the animal and on exposure length. The results reflect physiologically induced mitotic activity in specific classes of pituitary cells and further suggest that neuroendocrine mechanisms may be involved in control of cell turnover in the gland.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Termination of Lactation Induces Apoptosis and Alters the Expression of the Bcl-2 Family Members in the Rat Anterior Pituitary.
E. Ahlbom, L. Grandison, B. Zhivotovsky, and S. Ceccatelli (1998)
Endocrinology 139, 2465-2471
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Science. ISSN 0036-8075 (print), 1095-9203 (online)