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Science 20 February 1970:
Vol. 167. no. 3921, pp. 1136 - 1137
DOI: 10.1126/science.167.3921.1136
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Articles

Pseudohermaphrodite Rat: End Organ Insensitivity to Testosterone

C. Wayne Bardin 1, Leslie Bullock 1, George Schneider 1, John E. Allison 2, and Allan J. Stanley 2

1 Endocrinology Branch, National Cancer Institute, Bethesda, Maryland 20014
2 University of Oklahoma Medical Center, Oklahoma City

The pseudohermaphrodite rat is characterized by lack of androgen-dependent differentiation. Treatment of these rats with testosterone failed to produce the expected changes in preputial and adrenal gland weights and hexobarbital metabolism. This insitivity of the end organ to testosterone could not be explained by defective formation of dihydrotestosterone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Androgen Receptor Roles in Spermatogenesis and Fertility: Lessons from Testicular Cell-Specific Androgen Receptor Knockout Mice.
R.-S. Wang, S. Yeh, C.-R. Tzeng, and C. Chang (2009)
Endocr. Rev. 30, 119-132
   Abstract »    Full Text »    PDF »
Testosterone: a major determinant of extragenital sexual dimorphism.
C. Bardin and J. Catterall (1981)
Science 211, 1285-1294
   Abstract »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)