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Science 20 February 1970:
Vol. 167. no. 3921, pp. 1133 - 1134
DOI: 10.1126/science.167.3921.1133
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Articles

Late DNA Replication in Male Mouse Meiotic Chromosomes

N. Odartchenko 1 and M. Pavillard 1

1 Swiss Institute for Experimental Cancer Research, Bugnon 21. Lausanne, Switzerland

Parts of the male mouse meiotic complement comprising the Y chromosome, the whole X chromosome, and near-centromeric parts of autosomal bivalents are synthesized late, as judged by tritiated thymidine autoradiography. This confirms the occurrence of end-to-end association between X and Y chromosomes and suggests that paired heterochromatic segments in autosomes must synthesize DNA at the same time.


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Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist.
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Xist-deficient mice are defective in dosage compensation but not spermatogenesis..
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