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Science 13 February 1970:
Vol. 167. no. 3920, pp. 1003 - 1004
DOI: 10.1126/science.167.3920.1003
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Articles

Alanine: Key Role in Gluconeogenesis

Philip Felig 1, Thomas Pozefsk 1, Errol Marlis 1, and George F. Cahill 1

1 Elliott P. Joslin Research Laboratory, Harvard Medical School, Boston, Massachusetts 02215

Of 20 amino acids measured, alanine is the principal amino acid released by forearm muscle of man, in accord with its being the principal amino acid extracted by liver for gluconeogenesis. This occurs in both the postabsorptive state and after 4 to 6 weeks of starvation, when total amino acid release is markedly diminished.


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