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Science 6 February 1970:
Vol. 167. no. 3919, pp. 898 - 899
DOI: 10.1126/science.167.3919.898
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Articles

5-Hydroxytryptamine: A Cytospecific Growth Stimulator of Cultured Fibroblasts

Robert J. Boucek 1 and T. Ralph Alvarez 1

1 Laboratories for Cardiovascular Research, Howard Hughes Medical Institute and the Department of Medicine, University of Miami School of Medicine, Miami, Florida 33136

5-Hydroxytryptamine (serotonin) in micromolar amounts increased the growth of fibroblasts in culture while not affecting five other cell lines. Serotonin appeared to shorten the lag phase of cell growth. The effect was less when serotonin was added to the fibroblast culture after the initial 24-hour period. The two functional groups of the serotonin molecule were required for growth enhancement. Serotonin in millimolar concentrations was toxic to fibroblasts.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Idiopathic and L-Tryptophan-Associated Eosinophilic Fasciitis Before and After L-Tryptophan Contamination.
A. Blauvelt and V. Falanga (1991)
Arch Dermatol 127, 1159-1166
   Abstract »    PDF »
Myalgia and Eosinophilia Associated With Ingestion of Tryptophan: An Intriguing New Syndrome.
R. M. LEWKONIA (1990)
Arch Intern Med 150, 2005-2007
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)