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Science 6 February 1970:
Vol. 167. no. 3919, pp. 878 - 879
DOI: 10.1126/science.167.3919.878
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Articles

Metabolic Dependence of Fast Axoplasmic Transport in Nerve

Sidney Ochs 1 and N. Ranish 1

1 Department of Physiology, Indiana University Medical Center, Indianapolis

Fast axoplasmic transport, shown in cat sciatic nerves by a crest of labeled activity after injection of the L7 ganglion with [3H]-leucine or [ 3H]-lysine, was stopped within 15 minutes after death of the animals by bleeding. If the sciatic nerves were removed from the animals and placed in a chamber supplied with oxygen at 38 degrees centigrade, fast transport was sustained. Transport was rapidly blocked in similar in vitro preparations when the nerves were kept in a nitrogen environment. Fast axoplasmic transport is closely dependent upon oxibdative metabolism.


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