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Science 9 January 1970:
Vol. 167. no. 3915, pp. 195 - 196
DOI: 10.1126/science.167.3915.195
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Articles

Peroxidase-Mediated Virucidal Systems

Melvin E. Belding 1, Seymour J. Klebanoff 1, and C. George Ray 2

1 U.S. Public Health Service Hospital, Seattle, Washington 98114, and Department of Medicine, University of Washington School of Medicine, Seattle 98105
2 Department of Pediatrics and Microbiology, University of Washington School of Medicine

Peroxidase (myeloperoxidase or lactoperoxidase), hydrogen peroxide, and a halide such as iodide, bromide, or chloride form a potent virucidal system that is effective against polio and vaccinia viruis, particularly at a low pH. The peroxidase-halide-hydrogen peroxide system may contribute to the host defense against certain viral infections.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte.
E. P. Reeves, M. Nagl, J. Godovac-Zimmermann, and A. W. Segal (2003)
J. Med. Microbiol. 52, 643-651
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X-ray Crystal Structure and Characterization of Halide-binding Sites of Human Myeloperoxidase at 1.8 A Resolution.
T. J. Fiedler, C. A. Davey, and R. E. Fenna (2000)
J. Biol. Chem. 275, 11964-11971
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Oxidants and Antioxidants in Viral Diseases: Disease Mechanisms and Metabolic Regulation.
E. Peterhans (1997)
J. Nutr. 127 , 962S
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Myeloperoxidase Deficiency: Prevalence and Clinical Significance.
M. F. PARRY, R. K. ROOT, J. A. METCALF, K. K. DELANEY, L. S. KAPLOW, and W. J. RICHAR (1981)
Ann Intern Med 95, 293-301
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Nonimmunologic Aspects of Caries Resistance.
I. D. Mandel (1976)
Journal of Dental Research 55, C22-C31
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Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes.
S. J. Klebanoff (1970)
Science 169, 1095-1097
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