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Science 2 January 1970:
Vol. 167. no. 3914, pp. 56 - 58
DOI: 10.1126/science.167.3914.56
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Articles

Kasugamycin Resistance: 30S Ribosomal Mutation with an Unusual Location on the Escherichia coli Chromosome

P. Frederick Sparling 1

1 Department of Bacteriology and Immunology and Bacterial Physiology Unit, Harvard Medical School, Boston, Massachusetts

A mutation in Escherichia coli to resistance to the aminoglycoside antibiotic kasugamycin alters the 30S ribosomal subunit. Though all other known 30S ribosomal mutations are located in a cluster in the streptomycin region, kasugamycin resistance is located at a distance from this region, near the leucine region.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)